Each bottle contains 60 capsules, which is a 30-day supply.
Our unique blend of active vitamins, organic herbs, and amino acids may help:
• Target occasional stress*
• Enhance mental clarity*
• Support a better mood*
• Promote relaxation*
• Relax muscle tension*
VITAMINSUPPORT GUARANTEE:
• Fully Organic Herbal Powder (Not Extracts)
• We Only Use Active Vitamins In Our Products
• No Dyes, No Artificial Coloring, and No Magnesium Stearate
• Vegetarian Formula
Recommended Serving: Take 1 capsule in the morning and 1 capsule in the evening, preferably with food.
INGREDIENTS:
Herbs:
Organic Ashwagandha Root Powder (Withania somnifera) – Also known as ‘Indian Ginseng,’ Ashwagandha has been used in India for centuries to help boost energy levels as well as provide stress support [1, 2]. Ashwagandha also enhances cognitive processes, such as learning and memory function [3]. This potent herb also reinforces immune system health [4].
Organic Ginger Root Powder (Zingiber officinale) – Ginger may help support digestive health and occasional nausea [5]. This botanical helps minimize stomach discomfort and muscle spasms for people who have frequent digestive issues [6]. Ginger root also promotes relaxation by targeting anxiousness [7].
Organic Motherwort Herb Powder (Leonurus cardiaca) – Motherwort is a calming herb helpful for irritability [8]. In addition, Motherwort contains various antioxidants that help destroy harmful free radical toxins [8].
Organic Oat Seed Powder (Avena sativa) – Milky oats have been used historically for stress support and occasional sleeplessness [9, 10]. Oat seed helps minimize nervous tension, worry, and anxiousness that can disrupt sleep [9, 10]. Oats also contain selenium, tryptophan, and melatonin, all of which support relaxation and healthy sleep [9, 11].
Organic Passion Flower Herb Powder (Passiflora incarnata) – Passion Flower is known for its soothing properties and promoting relaxation [12]. This beneficial herb targets restlessness, fidgeting, racing thoughts, and nerve-related discomfort [13]. Passion flower influences chemicals in the brain such as gamma-aminobutyric acid (GABA), which support coping mechanisms for irritability, stress, and muscle tension [13].
Organic Phyllanthus (Bhumyamalaki) Herb Powder (Phyllanthus niruri) – Bhumyamalaki is an herb known for its antioxidant properties that help target free radical toxins and oxidative stress, which refers to an imbalance of toxins and antioxidants in the body [14, 15].
Organic Velvet Bean Seed Powder (Mucuna pruriens) – Also known as Mucuna pruriens or Mucuna beans, is an excellent source of antioxidants that help target harmful invaders and free radical toxins [16]. Velvet beans also contain an amino acid called L-Dopa, which the body uses to make a chemical in the brain called dopamine [17]. Dopamine helps transfer signals involved in concentration, alertness, mood, and memory [17]. Healthy dopamine levels also support better responses to stress [17].
Organic Valerian Root Powder (Valeriana officinalis) – Valerian has been used for thousands of years around the world to help ease restlessness, nervousness, and occasional sleeplessness [18-20]. Taking this herbs provides benefits in sleep quality and average sleep time, while minimizing the number of night time wakings and sleep latency, the time it takes to fall asleep [19, 20].
Amino acids:
GABA (gamma-aminobutyric acid) – GABA can help with occasional stress as well as support mental relaxation. GABA has a stress-minimizing and calming influence on the brain, similar to synthetic medications often prescribed for relaxation [21]. This chemical messenger in the brain combats stress and anxiousness by blocking nerve cells that overfire during stressful situations [21, 22].
L-Theanine as L-TeaActive® – L-Theanine as L-TeaActive® is an amino acid found in green tea that has been shown to influence brain activity by promoting relaxation, focus, and a healthy stress response [23]. The combination of GABA and L-Theanine helps lengthen sleep time and accelerates sleep onset [24].
L-Tryptophan – L-Tryptophan is an important amino acid that is converted to 5-hyrdoxytryptophan (5-HTP), and then to serotonin in the body [25]. Serotonin is a chemical messenger in the brain transmits signals between nerve cells and encourages a healthy mood. Taking L-Tryptophan helps target fatigue, hormonal imbalances, weakness, and headaches, all of which influence responses to stress and mood control [26].
Vitamins:
Folate - Folic acid supports cardiovascular and heart health [27]. In addition, folic acid heightens the body’s natural defenses against harmful agents that can damage cells throughout the body [27-31]. Folic acid also enhances brain health, boosts energy levels, minimizes fatigues, and targets invaders that are linked to abnormal inflammatory responses [27, 28].
Thiamin (as Thiamine HCL) – Thiamin is also known as Vitamin B1, and plays an important role in energy production in the body [32]. In addition, Thiamin is essential for a healthy nervous system and muscle function. Thiamin also reinforces red blood cell health and circulatory system function, both of which play role in endurance and stress response [32].
Vitamin B6 (as Pyridoxal-5-Phosphate) – Pyridoxine, also known as Vitamin B6, supports amino acid absorption and the production of neurotransmitters, chemical messengers in the brain [33]. In addition, pyridoxine reinforces healthy immune system and nervous system responses, which are processes that help the body cope with stress and discomfort [33].
Vitamin B12 (as Methylcobalamin) – Vitamin B12 promotes energy production and enhances nervous system health [34]. Furthermore, Vitamin B12 boosts red blood cell, immune cell, and nerve cell health by heightening nutrient transfer throughout the body [34, 35]. In addition, vitamin B12 bolsters mood and the ability to relax by influencing melatonin levels [36, 37]. Severe vitamin B deficiencies can lead to major health problems in the nervous system and brain [38]. Methylcobalamin is the bioactive form of vitamin B12 that the body easily uses.
Vitamin C (as Ascorbic Acid) – Vitamin C is essential for life. It is an extremely important vitamin that provides powerful antioxidant properties and reinforces healthy immune responses [39]. In addition, taking Vitamin C targets fatigue, especially lethargy that is linked to a vitamin C deficiency, and helps the body sustain optimal energy levels during stressful situations [39, 40].
Minerals:
Zinc (as Zinc Citrate) – Zinc is used by the immune system and it also provides antioxidant support. Zinc also promotes optimal brain health, and a deficiency of vital mineral may contribute to cognitive issues, such as memory impairments, learning problems, or a loss of mental clarity [41].
References
1. Bhattacharya SK, Bhattacharya A, Sairam K, et al. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: An experimental study. Phytomedicine. 2000;7(6):463-469.
2. Archana R, Namasivayam A. Antistressor effect of Withania somnifera. J Ethnopharmacol. 1999;64:91-93.
3. Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R. Randomized placebo-controlled adjunctive study of an extract of Withania somnifera for cognitive dysfunction in bipolar disorder. J Clin Psychiatry. 2013;74(11):1076-1083.
4. Ghosal S, Lal J, Srivastava R, and et al. Immunomodulatory and CNS effects of sitoindosides 9 and 10, two new glycowithanolides from Withania somnifera. Phytotherapy Research. 1989;3(5):201-206.
5. Dabaghzadeh F, Khalili H, Dashti-Khavidaki S, et al. Ginger for prevention of antiretroviral-induced nausea and vomiting: A randomized clinical trial. Expert Opin Drug Saf. 2014;13(7):859-866.
6. Hu ML, Rayner CK, Wu KL, et al. Effect of ginger on gastric motility and symptoms of functional dyspepsia. World J Gastroenterol. 2011;17:105-110.
7. Kazemian A, Toghiani A, Shafiei K, et al. Evaluating the efficacy of mixture of Boswellia carterii, Zingiber officinale, and Achillea millefolium on severity of symptoms, anxiety, and depression in irritable bowel syndrome patients. J Res Med Sci. 2017;22:120.
8. Wojtyniak K, Szymanski M, Matlawska I. Leonurus cardiaca L. (motherwort): A review of its phytochemistry and pharmacology. Phytother Res. 2013;27(8):1115-1120.
9. Dimpfel W, Storni C, Verbruggen M. Ingested oat herb extract (Avena sativa) changes EEG spectral frequencies in healthy subjects. J Altern Complement Med. 2011;17(5):427-434.
10. Kennedy DO, et al. Acute effects of a wild green-oat (Avena sativa) extract on cognitive function in middle-aged adults: A double-blind, placebo-controlled, within-subjects trial. Nutr Neurosci. 2017;20(2):135-151.
11. Xiao, Ya Li, Sha Li, et al. "Dietary sources and bioactivities of m Nutrients. 2017;9(4):367-431.
12. Akhondzadeh S, Naghavi HR, Vazirian M, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther. 2001;26(5):363-367.
13. Elsas SM, Rossi DJ, Raber J, et al. Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method. Phytomedicine. 2010;17(12):940-949.
14. Meena AK, Singh A, Rao MM. Evaluation of physicochemical and preliminary phytochemical studies on the fruit of Emblica officinalis gaertn. Asian J Pharm Clin Res. 2010;3(3):242-243.
15. Li Y, Sun HY, et al. Evaluation of cellular antioxidant and antiproliferative activities of five main Phyllanthus Emblica L. cultivars in China. Indian J Pharm Sci. 2015;77(3):274-82.
16. Mastan SA, Ramayya J, Mutyala Naidu L, et al. Antimicrobial activity of various extracts of Mucuna pruriens Biomed Pharmacol J. 2009;2(1).
17. Lampariello L, Cortelazzo A, Guerranti R. The magic velvet bean of Mucuna pruriens. J Tradit Complement Med. 2012;2(4):331-339.
18. Plushner SL. Valerian: Valerian officinalis. Am J Health Syst Pharm. 2000;57:328,333,335.
19. Wheatley D. Stress-induced insomnia treated with kava and valerian: singly and in combination. Hum Psychopharmacol. 2001;16:353-356.
20. Leathwood PD, Chauffard F, Heck E, Munoz-Box R. Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man. Pharmacol Biochem Behav. 1982;17:65-71.
21. Parch L. Antidotes to anxiety: Here is our guide to 8 calming supplements that can soothe a fretful mind. Natural Health. 2005;(7):95.
22. Emmons H. The chemistry of calm: How to support your brain with safe nutritional s Life Extension. 2011;17(3):1-8.
23. Einöther SJ, Martens VE. Acute effects of tea consumption on attention and mood. Am J Clin Nutr. 2013;98(6 Suppl):1700S-1708S.
24. Kim S, Jo K, Hong K-B, Han SH, Suh HJ. GABA and l-theanine mixture decreases sleep latency and improves NREM sleep. Pharmaceutical biology. 2019;57(1):65-73.
25. Jenkins TA, Nguyen JC, et al. Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain a Nutrients. 2016;8(1):E56.
26. Hou Y, Wu G. Nutritionally essential amino a Adv Nutr. 2018;9(6):849-851.
27. Homocysteine Lowering Trialists' Collaboration. Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr. 2005;82(4):806-812.
28. Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016 Jan 27;8(2):68.
29. Chen P, Li C, et al. Higher dietary folate intake reduces the breast cancer risk: a systematic review and meta-analysis. Br J Cancer. 2014;110(9):2327-38.
30. He H, Shui B. Folate intake and risk of bladder cancer: a meta-analysis of epidemiological studies. Int J Food Sci Nutr. 2014;65(3):286-292.
31. Lin HL, An QZ, et al. Folate intake and pancreatic cancer risk: an overall and dose-response meta-analysis. Public Health. 2013;127(7):607-613.
32. Kerns JC, Gutierrez. Thiamin. Adv Nutr. 2017;8(2):395-397.
33. Maggini S, Wintergerst ES, Beveridge S, Hornig DH. Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. Br J Nutr. 2007;98 Suppl 1:S29-S35.
34. O'Leary F, Samman S. Vitamin B12 in health and disease. Nutrients. 2010;2(3):299-316.
35. Mayer G, Kroger M, Meier-Ewert K. Effects of vitamin B12 on performance and circadian rhythm in normal subjects. Neuropsychopharmacology. 1996;15:456-464.
36. Troesch B, Hoeft B, McBurney M, et al. Dietary surveys indicate vitamin intakes below recommendations are common in representative western countries. Br J Nutr. 2012;108:692-698.
37. Mauro GL, et al.Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2000;4(3):53-58.
38. Ekabe CJ, Kehbila J, Abanda MH, et al. Vitamin B12 deficiency neuropathy; a rare diagnosis in young adults: A case report. BMC Res Notes. 2017;10:72.
39. Padayatty SJ, Levine M. New insights into the physiology and pharmacology of vitamin C. CMAJ. 2001;164:353-355.
40. Peters EM, Anderson R, Nieman DC, et al. Vitamin C supplementation attenuates the increases in circulating cortisol, adrenaline and anti-inflammatory polypeptides following ultramarathon running. Int J Sports Med. 2001;22:537-543.
41. Roohani N, Hurrell R, Kelishadi R, Schulin R. Zinc and its importance for human health: An integrative review. J Res Med Sci. 2013;18(2):144-157.
Fillers: We do NOT use Magnesium Stearate.
VitaminSupport does NOT use any artificial fillers in our product. One popular filler, also known as a “flow agent”, that is commonly used in supplements is magnesium stearate. This filler is used to easily fill the capsules during production. Some studies have shown that fillers such as magnesium stearate may reduce the absorption of the vitamins and nutrients in the body. (http://www.ncbi.nlm.nih.gov/pubmed/3735097) At VitaminSupport, we refuse to cut corners and compromise our products.
Warnings: As with any supplement, if you are taking medication or have a medical condition, consult your doctor before use. This supplement is NOT formulated for use by children or those who are pregnant or lactating. Do not exceed the recommended use. May cause drowsiness, do not operate machinery.
SleepSupport was designed to help target stress and promote relaxation.*
Each bottle contains 60 capsules, which is a 30-day supply.
• Fully Organic Herbal Powder (Not Extracts)
• We Only Use Active Vitamins In Our Products
• No Dyes, No Artificial Coloring, and No Magnesium Stearate
• Vegetarian Formula
Recommended Serving: Take 1 to 2 capsules 30 minutes before bed.
INGREDIENTS:
Herbs:
Organic Ashwagandha Root Powder (Withania somnifera) – Also known as ‘Indian Ginseng,’ Ashwagandha has been used in India for centuries to help boost energy levels and provide stress support [1, 2]. Ashwagandha also heightens cognitive functions, such as thought processing and memory function [3]. Enhancing these processes can help minimize nervous tension and racing thoughts that can disrupt sleep. This potent herb also reinforces immune system health [4].
Organic Hops (Humulus lupulus) – Hops may help minimize stress and occasional anxiousness that is associated with sleeplessness [5]. This beneficial botanical promotes relaxation by targeting restlessness, mental tension, and nervousness that is linked to sleep disturbances [5, 6].
Organic Wild Lettuce (leaf) (Lactuca virosa) – Wild lettuce has been used historically to minimize sleeplessness, target occasional anxiousness, and help fight other common health problems, such as physical discomfort that disrupts sleep [7, 8].
Organic Valerian (Valeriana officinalis) – Valerian has been used for thousands of years around the world to combat numerous issues including restlessness, anxiousness, nervousness, and sleeplessness [9]. Valerian root heightens sleep quality by lengthening average sleep time, minimizing the number of night time awakenings, and accelerating sleep latency, the time it takes to fall asleep [9-11]. This potent herb also helps minimize daytime sleepiness [9].
Organic Passion Flower (Passiflora incarnata) – Passionflower is used to help minimize sleeplessness by providing relaxation support [12]. This beneficial herb targets restlessness, fidgeting, racing thoughts, and nerve-related discomfort that can disrupt sleep [13]. Passion flower influences chemicals in the brain such as gamma-aminobutyric acid (GABA), which support coping mechanisms for irritability, stress, and muscle tension [13].
Amino Acids
L-Theanine – L-Theanine is an amino acid found in green tea that has been shown to have a direct influence on brain activity by promoting relaxation and focus [14]. Taking L-Theanine also reinforces healthy stress responses by balancing cortisol levels, the stress hormone that is released during difficult situations [14]. In addition, L-Theanine works with GABA to help lengthen sleep time and accelerate sleep onset [15].
Glycine – Glycine is a sweet-tasting, non-essential amino acid that has a multitude of benefits in the body, including enhanced sleep quality and minimized daytime sleepiness [16]. Furthermore, Glycine helps trigger a drop in body temperature in preparation for sleep, and it also promotes quicker sleep onset as well as more time spent in rapid eye movement (REM) sleep [16, 17]. In addition, Glycine supplementation bolsters serotonin levels, which can reinforce healthy sleep patterns, while encouraging deeper, more restful, and refreshing sleep [17]. Taking Glycine regularly also supports healthy inflammatory responses [16, 17].
L-Tryptophan – Tryptophan is an important amino acid that the body converts to 5-hyrdoxytryptophan (5-HTP) and then to serotonin [18]. Serotonin is a chemical messenger in the brain that transmits signals between nerve cells and supports a healthy mood [18, 19]. Taking Tryptophan helps target fatigue, hormonal imbalances, weakness, and headaches, all of which influence responses to stress, mood control, and sleep patterns [19].
Minerals
Magnesium Citrate – An essential mineral that supports brain health, bolsters energy, helps ease stress, and relaxes tight muscles [20]. Magnesium regulates chemical messengers in the brain called neurotransmitters that send signals throughout the nervous system [20]. This process helps target anxiousness, nervousness, and restlessness that can contribute to sleep disturbances [21, 22]. This powerful mineral also influences melatonin production, which supports a healthy sleep/wake cycle [22]. Magnesium in the form of Magnesium Citrate is more absorbable than other commonly available forms.
Hormones
Melatonin – A hormone produced in the small pineal gland of the brain that signals the body when it’s time to go to sleep [23]. Melatonin supplementation can be used safely to help with restlessness and sleeplessness [24, 25]. Taking Melatonin for occasional sleep problems help enhance sleep quality by minimizing the amount of time it takes to fall asleep [23-25].
References
1. Bhattacharya SK, Bhattacharya A, Sairam K, et al. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: An experimental study. Phytomedicine. 2000;7(6):463-469.
2. Archana R, Namasivayam A. Antistressor effect of Withania somnifera. J Ethnopharmacol. 1999;64:91-93.
3. Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R. Randomized placebo-controlled adjunctive study of an extract of Withania somnifera for cognitive dysfunction in bipolar disorder. J Clin Psychiatry. 2013;74(11):1076-1083.
4. Ghosal S, Lal J, Srivastava R, and et al. Immunomodulatory and CNS effects of sitoindosides 9 and 10, two new glycowithanolides from Withania somnifera. Phytotherapy Research. 1989;3(5):201-206.
5. Behr J, Vogel RF. Mechanisms of hop inhibition include the transmembrane redox reaction. Appl Environ Microbiol. 2010;76(1):142-149.
6. Cornu C, Remontet L, Noel-Baron F, et al. A dietary supplement to improve the quality of sleep: A randomized placebo-controlled trial. BMC Complement Altern Med. 2010;10:29.
7. Gumprecht T. On the use of Lactuca Virosa, in whooping-cough. Med Chir Trans. 1815; 6: 608–617.
8. Shi M, Gu J, Wu H, et al. Phytochemicals, nutrition, metabolism, bioavailability, and health benefits in lettuce: A comprehensive review. Antioxidants (Basel). 2022;11(6):1158.
9. Kennedy DO, Little W, Haskell CF, et al. Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress. Phytother Res. 2006;20:96-102.
10. Plushner SL. Valerian: Valerian officinalis. Am J Health Syst Pharm. 2000;57:328,333,335.
11. Wheatley D. Stress-induced insomnia treated with kava and valerian: Singly and in combination. Hum Psychopharmacol. 2001;16:353-6.
12. Akhondzadeh S, Naghavi HR, Vazirian M, et al. Passionflower in the treatment of generalized anxiety: A pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther. 2001;26(5):363-367.
13. Elsas SM, Rossi DJ, Raber J, et al. Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method. Phytomedicine. 2010;17(12):940-949.
14. Einöther SJ, Martens VE. Acute effects of tea consumption on attention and mood. Am J Clin Nutr. 2013;98(6 Suppl):1700S-1708S.
15. Kim S, Jo K, Hong K-B, Han SH, Suh HJ. GABA and l-theanine mixture decreases sleep latency and improves NREM sleep. Pharmaceutical biology. 2019;57(1):65-73.
16. Kawai N, Sakai, Okuro M, et al. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. Neuropsychopharmacology. 2015;40(6):1405-1416.
17. Yamadera W, Inagawa K, Chiba S, et al. Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep and Biol Rhythms. 2007;5(2):126-131.
18. Jenkins TA, Nguyen JC, et al. Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis. Nutrients. 2016;8(1):E56.
19. Hou Y, Wu G. Nutritionally essential amino acids. Adv Nutr. 2018;9(6):849-851.
20. Boyle NB, Lawton C, Dye L. The effects of magnesium supplementation on subjective anxiety and stress-A systematic rNutrients. 2017;9(5):E429. doi: 10.3390/nu9050429.
21. Hanus M, Lafon J, Mathieu M. Double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate anxiety disorders. Curr Med Res Opin. 2004;20:63-71.
22. Kirkland AE, Sarlo GL, Holton K. The role of magnesium in neurological dNutrients. 2018;10(6):E730.
23. Damiani JM, Sweet BV, Sohoni P. Melatonin: An option for managing sleep disorders in children with autism spectrum disorder. Am J Health Syst Pharm. 2014;71(2):95-101.
24. Sletten TL, Magee M, et al. Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomized clinical t PLoS Med. 2018;15(6):e1002587.
25. Xie Z, Chen F, William AL, et al. A review of sleep disorders and melatonin. Neurol Res. 2017;39(6):559-565.
Fillers: We do NOT use Magnesium Stearate.
VitaminSupport does NOT use any artificial fillers in our product. One popular filler, also known as a "flow agent", that is commonly used in supplements is magnesium stearate. This filler is used to easily fill the capsules during production. Some studies have shown that fillers such as magnesium stearate may reduce the absorption of the vitamins and nutrients in the body. (http://www.ncbi.nlm.nih.gov/pubmed/3735097) At VitaminSupport, we refuse to cut corners and compromise our products.
Warnings: As with any supplement, if you are taking medication or have a medical condition, consult your doctor before use. This supplement is NOT formulated for use by children or those pregnant or lactating. Do not exceed the recommended use. May cause drowsiness, do not operate machinery.