ImmuneSupport was designed as a daily supplement.
(Each bottle contains 60 capsules, which is a 30-day supply.)

     • Fully Organic Herbal Powder (Not Extracts)
     • We Only Use Active Vitamins In Our Products
     • No Dyes, No Artificial Coloring, and No Magnesium Stearate
     • Vegetarian Formula
     • Broad Spectrum Formula

Recommended Serving: Take 1 capsule in the morning and 1 capsule in the evening, preferably with food.


INGREDIENTS:

Vitamins:
Vitamin A (as beta carotene) – Vitamin A is a major fat-soluble antioxidant that supports healthy immune function. This essential vitamin reinforces the production and activity of different types of immune cells that play a key role in the body’s natural immune response to foreign invaders [1, 2].

Vitamin C (as ascorbic acid) – Vitamin C is essential for life. It is an extremely important vitamin that provides powerful antioxidant properties and promotes healthy immune responses [3]. Vitamin C supplementation enhances immune responses to stress by supporting an optimal balance of cortisol, the stress hormone that is released during difficult situations [4]. In addition, this powerful antioxidant assists the immune system by targeting free radical toxins and oxidative stress, which refers to an imbalance of toxins and antioxidants in the body [5].

Vitamin D3 (as cholecalciferol) – Vitamin D is a hormone-like vitamin that is made in the skin following adequate sun exposure, but it can also be taken as a supplement. Vitamin D has a wide variety of benefits in the body including reinforcing a healthy immune system [6]. This versatile vitamin helps the immune system by enhancing the activity of immune cells as well as the enzymes that convert vitamin D3 into an active form the body uses to make powerful proteins that target harmful invaders [6, 7].

Vitamin B12 (as Methylcobalamin) – Vitamin B12 promotes energy production and enhances nervous system health [8]. Furthermore, Vitamin B12 boosts red blood cell, immune cell, and nerve cell health by heightening nutrient transfer throughout the body [9, 10]. Severe vitamin B deficiencies can lead to major health problems in the immune system, nervous system, and brain [11]. Methylcobalamin is the bioactive form of vitamin B12 that the body easily uses.

Minerals:
Zinc (as zinc citrate) – Zinc is used by the immune system and it also provides antioxidant support. Adequate levels of zinc enhance the production and activity of immune cells [12]. Taking zinc regularly and boosting the serving at the first sign of a cold, can also help shorten the severity and duration of the common cold [13]. Zinc also has antioxidant properties that scavenge free radical toxins and minimize oxidative stress, which are factors that are linked to various health problems [14, 15]. The immune system is susceptible to changes in zinc levels, especially a zinc deficiency [12].

Selenium (as selenium glycinate) – Selenium is an antioxidant that has many positive functions in the body. It is essential for proper immune function. Selenium also helps regenerate glutathione, another important antioxidant that bolsters the activity of enzymes that heighten immune responses by helping expel toxins from the liver [16, 17]. In addition, selenium helps scavenge free radical toxins and other invaders to enhance overall health [18, 19]. Furthermore, selenium binds to mercury and other heavy metals, which helps flushes them out of the bloodstream and body [20]. This blocks the buildup of metals in vital organs and fatty tissue where they can lead to health problems including skin, nail, and hair issues [18-20].

Amino Acids:
N-Acetyl Cysteine (NAC) – NAC is an amino acid the body uses to make glutathione, an important antioxidant. NAC supports respiratory and immune function [21, 22]. Taking NAC helps boost energy throughout the day, minimizing the sluggish feeling that often develops mid-morning [21, 22].

Herbs:
Organic Astragalus (Astragalus membranaceus) – Astragalus falls into the category of herbs called adaptogens, which help the body adapt to different types of environmental and biological stressors [23]. Taking astragalus supports a healthy immune system. Astragalus reinforces the body's vital Qi, facilitates urination, promotes purulent discharge, and enhances soft tissue repair and growth [24].

Organic Echinacea (root) (Echinacea angustifolia) – Echinacea has been widely used for supporting healthy immune function [25]. This beneficial herb enhances immune responses by boosting the production of immune cells that fight invaders linked to health issues [26]. Echinacea also helps the liver naturally cleanse the bloodstream [27].

Organic Ashwagandha Root Powder (Withania somnifera) – Also known as ‘Indian Ginseng,’ Ashwagandha has been used in India for centuries to help boost energy levels and provide stress support [28, 29]. Ashwagandha also enhances cognitive processes, such as learning and memory function [30]. This potent herb also reinforces immune system health [31].

Organic Elderberry (fruit) (Sambucus nigra) – Elderberry has been used for centuries to help maintain a healthy immune response [32]. This potent botanical is an excellent source of invader-fighting antioxidants [33, 34]. It also targets certain invaders directly by blocking their ability to reproduce [35, 36]. In addition, elderberry bolsters the liver’s natural cleansing ability [36].

Organic Maitake Mushroom (Grifola frondosa) – Maitake is an important Asian medicinal mushroom with centuries of use. Extracts of Maitake have potent immune-enhancing properties [37]. This well-known adaptogen also refines the body’s response to stress and optimizes internal pH, which are processes that promote better health [37, 38]. Furthermore, Maitake enhances the body’s innate defenses by heightening natural antioxidant activity that combats toxins and invaders [37-39].

Organic Reishi Mushroom (Ganoderma lucidum) – Reishi mushroom is traditional Asian medicinal mushroom that has been used extensively over thousands of years for different health problems [40]. Historically it has been used to help bolster energy, immune function, and memory function [41]. Reishi mushroom has unmatched potency and it contains high concentrations of active compounds, such as polyphenols, polysaccharides, and triterpenoids, that have powerful antioxidant and invader-fighting properties [41, 42]. The potent compounds are also described through research as “pharmaceutically active” [42].

References
1. Chang HK, Hou WS. Retinoic acid modulates interferon-γ production by hepatic natural killer T cells via phosphatase 2A and the extracellular signal-regulated kinase pathway. J Interferon Cytokine Res. 2015;35(3):200-212.

2. Huang Z, Liu Y, et al. Role of vitamin A in the immune system. J Clin Med. 2018;7(9):E258.

3. Padayatty SJ, Levine M. New insights into the physiology and pharmacology of vitamin C. CMAJ. 2001;164:353-355.

4. Peters EM, Anderson R, Nieman DC, et al. Vitamin C supplementation attenuates the increases in circulating cortisol, adrenaline and anti-inflammatory polypeptides following ultramarathon running. Int J Sports Med. 2001;22:537-543.

5. Hemila H. Vitamin C intake and susceptibility to the common cold. Br J Nutr. 1997;77:59-72.

6. Hewison M. Vitamin D and immune function: An overview. Proc Nutr Soc. 2012;71(1):50-61.

7. Turnbull ER, Drobniewski F. Vitamin D supplementation: A comprehensive review on supplementation for tuberculosis prophylaxis. Expert Rev Respir Med. 2015;9(3):269-275.

8. O'Leary F, Samman S. Vitamin B12 in health and disease. Nutrients. 2010;2(3):299-316.

9. Mayer G, Kroger M, Meier-Ewert K. Effects of vitamin B12 on performance and circadian rhythm in normal subjects. Neuropsychopharmacology. 1996;15:456-464.

10. Troesch B, Hoeft B, McBurney M, et al. Dietary surveys indicate vitamin intakes below recommendations are common in representative western countries. Br J Nutr. 2012;108:692-698.

11. Ekabe CJ, Kehbila J, Abanda MH, et al. Vitamin B12 deficiency neuropathy; a rare diagnosis in young adults: A case report. BMC Res Notes. 2017;10:72.

12. Gammoh NZ, Rink L. Zinc in infection and inflammation. Nutrients. 2017;9(6):E624.

13. Science M, Johnstone J, Roth DE, et al. Zinc for the treatment of the common cold: A systematic review and meta-analysis of randomized controlled trials. CMAJ. 2012;184:E551-61.

14. Valko M, Leibfritz D, Moncol J, et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39(1):44-84.

15. Prasad AS. Zinc: An antioxidant and anti-inflammatory agent: role of zinc in degenerative disorders of aging. J Trace Elem Med Biol. 2014;28(4):364-371.

16. Gärtner R, Gasnier BC, Dietrich JW, et al. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations. J Clin Endocrinol Metab. 2002;87(4):1687-1691.

17. Allen J, Bradley RD. Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. J Altern Complement Med. 2011;17(9):827-833.

18. Fan Y, Xu S, Zhang H, et al. Selenium supplementation for autoimmune thyroiditis: A systematic review and meta-Analysis. Int J Endocrinol. 2014;2014:904573.

19. Sugiura Y, Tamai Y, Tanaka H. Selenium protection against mercury toxicity: High binding affinity of methylmercury by selenium-containing ligands in comparison with sulfur-containing ligands. Bioinorg Chem. 1978;9(2):167-180.

20. Skerfving S. Interaction between selenium and methylmercury. Environ Health Perspect. 1978;25:57-65.

21. Chan A, Remington R, Kotyla E, et al. A vitamin/nutraceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. J Nutr Health Aging. 2010. 14(3):224-30.

22. Hou Y, Wu G. Nutritionally Essential Amino Acids. Adv Nutr. 2018;9(6):849-851.

23. Zhang HW, Lin ZX, Xu C, Leung C, Chan LS, Zhang HW. Astragalus (a traditional Chinese medicine) for treating chronic kidney disease. Cochrane Database Syst Rev. 2014;(10):CD008369.

24. Liu P, Zhao H, Luo Y. Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic. Aging Dis. 2017;8(6):868-886.

25. Karsch-Völk M, Barrett B, Linde K. Echinacea for preventing and treating the common cold. JAMA. 2015;313(6):618-619.

26. Kim HR, Oh SK, et al. Immune enhancing effects of Echinacea purpurea root extract by reducing regulatory T cell number and function. Nat Prod Commun. 2014;9(4):511-514.

27. Rezaie A, Fazlara A, et al. Effects of Echinacea purpurea on Hepatic and Renal Toxicity Induced by Diethylnitrosamine in Rats. Jundishapur J Nat Pharm Prod. 2013;8(2):60-64.

28. Bhattacharya SK, Bhattacharya A, Sairam K, et al. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: An experimental study. Phytomedicine. 2000;7(6):463-469.

29. Archana R, Namasivayam A. Antistressor effect of Withania somnifera. J Ethnopharmacol. 1999;64:91-93.

30. Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R. Randomized placebo-controlled adjunctive study of an extract of Withania somnifera for cognitive dysfunction in bipolar disorder. J Clin Psychiatry. 2013;74(11):1076-1083.

31. Ghosal S, Lal J, Srivastava R, and et al. Immunomodulatory and CNS effects of sitoindosides 9 and 10, two new glycowithanolides from Withania somnifera. Phytotherapy Research. 1989;3(5):201-206.

32. Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 2001;12:290-6.

33. Zakay-Rones Z, Thom E, Wollan T, Wadstein J. Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections. J Int Med Res 2004;32:132-40.

34. Zakay-Rones Z, Varsano N, Zlotnik M, et al. Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama. J Altern Complement Med. 1995;1:361-36

35. Roschek B, Fink RC, McMichael MD, et al. Elderberry flavonoids bind to and prevent H1N1 infection in vitro. Phytochemistry. 2009;70:1255-1261.

36. Ulbricht C, Basch E, et al. An evidence-based systematic review of elderberry and elderflower (Sambucus nigra) by the Natural Standard Research Collaboration. J Diet Suppl. 2014;11(1):80-120.

37. Zhang Y, Mills GL, Muraleedharan G. Cyclooxygenase inhibitory and antioxidant compounds from the mycelia of the edible mushroom Grifola frondosa. J Agric Food Chem. 2002;50(26):7581-7585.

38. Vetvicka V, Vetvickova J. Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts. Ann Transl Med. 2014;2(2):14.

39. Lei H, Zhang M, Wang Q, et al. MT-α-glucan from the fruit body of the maitake medicinal mushroom Grifola frondosa (higher Basidiomyetes) shows protective effects for hypoglycemic pancreatic β-cells. Int J Med Mushrooms. 2013;15(4):373-381.

40. Ma B, Ren W, Zhou Y, et al. Triterpenoids from the spores of Ganoderma lucidum. N Am J Med Sci. 2011;3(11):495-498.

41. Jong SC, Birmingham JM. Medicinal benefits of the mushroom Ganoderma. Adv Appl Microbiol. 1992; 37:101-34.

42. Boh B, Berovic M, Zhang J, Zhi-Bin L. Ganoderma lucidum and its pharmaceutically active compounds. Biotechnol Annu Rev. 2007;13:265–301.

Fillers: We do NOT use Magnesium Stearate.
VitaminSupport does NOT use any artificial fillers in our product. One popular filler, also known as a "flow agent", that is commonly used in supplements is magnesium stearate. This filler is used to easily fill the capsules during production. Some studies have shown that fillers such as magnesium stearate may reduce the absorption of the vitamins and nutrients in the body. (http://www.ncbi.nlm.nih.gov/pubmed/3735097) At VitaminSupport, we refuse to cut corners and compromise our products.

Warnings: As with any supplement, if you are taking medication or have a medical condition, consult your doctor before use. This supplement is NOT formulated for use by children or those who are pregnant or lactating. Do not exceed the recommended use.

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